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KMID : 0624620120450020085
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BMB Reports
2012 Volume.45 No. 2 p.85 ~ p.90
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CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway
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Kang Bo-Ram
Kim Ho
Nam Sung-Hee
Yun Eun-Young
Kim Seong-Ryul
Ahn Mi-Young
Chang Jong-Soo
Hwang Jae-Sam
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Abstract
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Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway.
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KEYWORD
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Anti-cancer effect, Apoptosis, Caspase-independent apoptosis pathways, Cell membrane penetration, Insect peptide, Leukemia
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